Sympathetic nervous system: (fight or flight): the first neuron has a short axon and the second one has a long one main neurotransmitters that are involved: acetylcholine and norepinephrine thorocolumbar region of the spine Parasympathetic nervous system (rest or digest): it has nerves in the cranial and the sacreal region its long and then short the main neurotransmitter: ACH (acetylcholine)