Limited drug-drug interactions have been seen with tapentadol due to the pharmacokinetic profile. Tapentadol does not appear to inhibit or induce the CYP450 enzyme system because it is mainly metabolized by glucuronidation. Because tapentadol does not produce active metabolites, dosing adjustment is not necessary in mild to moderate renal impairment. Tapentadol should be avoided in patients currently taking MAOIs and those who have taken MAOIs within the last 14 days. Tapentadol is currently available in an immediate-release formulation.