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CNS Pharmacology

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Pregunta:

Effect on dopaminergic tracts

Autor: Suzuki



Respuesta:

Mesocortical-mesolimbic dopamine receptor blockade presumably underlies antipsychotic effects, and a similar action on the chemoreceptor trigger zone leads to the useful antiemetic properties of some antipsychotic drugs. Adverse effects resulting from receptor blockade in the other dopaminergic tracts, a major problem with older antipsychotic drugs, include extrapyramidal dysfunction and hyperprolactinemia. Note that almost all antipsychotic agents block both α1 and histamine H1 receptors to some extent.


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Autor

Suzuki
Suzuki