4. Overdoses:

Seizures are a possibility because all antidepressants may lower the seizure threshold. All SSRIs have the potential to cause a serotonin syndrome that may include the symptoms of hyperthermia, muscle rigidity, sweating, myoclonus (clonic muscle twitching), and changes in mental status and vital signs when used in the presence of a MAOI or other highly serotonergic drug. Therefore, extended periods of washout for each drug class should occur prior to the administration of the other class of drugs.