How is immunotherapy w/immune checkpoints inhibitors?

— Based on mAb that inhibit checkpoint molecules: PD-1 /PD-L1 and CTLA4 — Reactivates T cells in the tumor microenvironment — Is one of the most successful cancer therapies in recent years Anti-PD1 and antiPD-L1 mAb revert tumor tolerance by CTL Anti-CTLA4 mAb reverse inhibition of T cell activation