Pregunta:
Describe the two pathways of resistance to checkpoints of tumors?
Autor: H KRespuesta:
Resistance through CTLA4: CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is an analog of CD28 expressed on activated T cells and on Treg It binds B7-1 or B7-2 and blocks signaling through C Resistance through PD1-PD1L: The PD-1 (programmed cell death-1) receptor and its ligands, PDL1/PD-L2, are members of the family of immune checkpoint proteins: PD-L1 and PD-L2 are commonly expressed by dendritic cells and macrophages Normally, PD-1 is increasingly expressed on activated T cells to halt or inhibit immune responses The PD-1/PD-L1 pathway is a resistance mechanism of tumor cells: PD-L1 is overexpressed on tumor cells or on non-transformed cells in the tumor microenvironment Its binding to PD-1 receptors on activated T cells leads to persistent CTL inhibition in the tumor microenvironment
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