What is proposed role of PD1 in establishment and reverasl of HIV latency?

— HIV infects CD4+T cells — Ag- or mitogen-stimulated T produce HIV virions and die by virus-mediated cytolysis. — Upregulated expression of immune checkpoint molecules limits T cell activation, favouring latent infection (integration of HIV progenome (yellow oval) but no virus production. — Administration of anti-PD1 antibody leads to activation of these T cells and increased production of virus — This leads to either immunemediated clearance or virusinduced cell de