How is use of total human Ig in infection prevention?

— IMIgs are used since 1952 in Ig replacement in patients with congenital humoral immunodeficiency (Bruton disease, common variable immunodeficiency) — Objective: maintain constant blood IgG concentration > 500 mg/dl (50% at least of normal concentration) — IMIG are poorly efficient and are now replaced by IVIg — IVIG are administred in perfusion : 400-500 mg/kg every 3 to 4 weeks — IVIg subcutaneous administration (smaller amounts, more frequently, self administration) allows higher patient autonomy