How is use of total human Igs?

— Total immunoglobulin fraction purified from a pool of plasma derived from several thousand random adult healthy individuals, by cold ethanol fractionation — Contains 98% IgG, traces of IgA and IgM — Contains immunoglobulins with billions of different antigenic specificities — Includes a large spectrum of antimicrobial antibodies, each in tiny amounts — Two forms: — Intramuscular immunoglobulins (IMIG — Intravenous immunoglobulins (IVIG): obtained by nanofiltration of IMIG, may also be used subcutaneously