How is selection of adjuvants?

— Adjuvant: a substance added in the vaccine that potentiates or modulates the immune response to the antigenic components — Not needed in attenuated, inactivated and recombinant vectors vaccines — Needed in purified proteins, peptides and polysaccharides vaccines — Can be natural (PAMP) or synthetic. Are usually TLR agonists that drive dendritic cell maturation — Other roles: delay of vaccine breakdown (emulsions, mineral salts… ), recruitment of leukocytes — Are the focus of the most recent developments in vaccinology — Modulate qualitatively the immune response : TH2 (humoral) or TH1 (cellular)