What is celiac disease?

➢ Gluten is a protein commonly found in wheat, rye, barley and other grains ➢ Both celiac disease and allergy (type I HS) can be triggered by gluten proteins although these responses involve different immunological mechanisms ➢ Celiac disease is classified as a Type IV HS mediated by Tcell responses whereas allergy is usually classed as a Type I HS mediated by E-type Igs (IgE antibodies). ➢ Celiac disease serves as the best example of delayed HS reactions associated with foods. Celiac disease results from activation of both a cell-mediated (T-cell) and humoral (B-cell) immune response. This activation results from exposure to the glutens