What are clinical manifestations of ACD?

➢ The clinical manifestations of ACD are the result of a T cell-mediated inflammatory reaction occurring in the skin upon re-exposure to the offending hapten (elicitation phase) and mediated by the activation of hapten-specific T cells in the skin. ➢ The primary effector cells of ACD appear to be CD8+ cells. ➢ The inflammatory reaction occurs 48 to 72 hours after exposure. ➢ REGULATORY MECHANISMS OF ACD — Regulatory T cells (Treg) may have a role in the sensitization and elicitation phase of ACD and in the down regulation of the inflammatory response ➢ Contact dermatitis is a common inflammatory skin condition characterized by erythematous and pruritic skin lesions after contact with a foreign substance