How is presentation of atopic dermatitis?

➢ A prolonged IgE-induced reaction causes atopic dermatitis, a skin condition characterized by persistent itching and scaly red patches. ➢ These often develop at sites where the skin is bent, such as the elbows and knees ➢ The persistence is due to the influx of mast cells and mainly eosinophiles stimulated by the continued presence of the allergen, which is often a harmless substance such as animal hair or dander. ➢ AD is now understood to be a much more heterogeneous disease, with additional activation of TH22, TH17/IL-23, and TH1 cytokine pathways depending on the subtype of the disease