What are clinical features of HSP?

➢ IC glomerulonephritis, as seen in Henoch-Schönlein purpura is an example of IgA involvement in a nephropathy. ➢ The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunlogic memory of the precipitating antigen. ➢ Typically, clinical features emerge a week following initial antigen challenge, when the deposited ICs can precipitate an inflammatory response. ➢ The classic clinical findings of palpable purpura in HSP are often preceded by viral respiratory illness. ➢ HSP is more common in children but can also occur in adults. Children may develop systemic disease with GI, joint, and/or kidney involvement. ➢ In adults, arthritis and kidney disease occur more frequently. HSP in adults, especially older men, may be associated with malignancy