What is Henoch-Schönlein Purpura (HSP)?

➢ Henoch-Schönlein purpura (HSP), a specific subtype of LCV , is characterized by predominant IgA-mediated vessel injury ➢ It is an acute IgA–mediated disorder characterized by a generalized vasculitis involving the small vessels of the skin, the gastrointestinal (GI) tract, the kidneys, the joints, and, rarely, the lungs and the central nervous system (CNS) The typical prodrome of HSP includes the following: – Headache – Anorexia – Fever Then Rash (90-100% in legs hallmark), Abdominal pain and vomiting (35-85%), Joint pain (60-84% Knees), Subcutaneous edema (20-50%)