How is infectious vasculitis?

➢ When an adaptive antibody response fails to clear an infectious agent, for example in subacute bacterial endocarditis or chronic viral hepatitis. ➢ In this situation, the multiplying bacteria or viruses are continuously generating new antigen in the presence of a persistent antibody response that fails to eliminate the organism. ➢ ICs disease ensues, with injury to small blood vessels in many tissues and organs, including the skin, kidneys, and nervesOther causes of infectious vasculitis; Post streptococcal glomerulonephritis (in fighting a strep infection, the patient makes an antibody that reacts against the strep but also cross-reacts with some antigen in the glomerulus; ICs lodge there and cause nephritis), Hepatitis, Meningitis, Mononucleosis, Malaria, Lyme arthritis, Trypanosomiasis,…