How is bullous pemphigoid morphology?

➢ Bullous pemphigoid is associated with tense subepidermal bullae filled with clear fluid ➢ The overlying epidermis characteristically lacks acantholysis. ➢ Early lesions show variable numbers of eosinophils at the dermal-epidermal junction, occasional neutrophils, superficial dermal edema, and associated basal cell layer vacuolization. ➢ The vacuolated basal cell layer eventually gives rise to a fluidfilled blister ➢ The blister roof consists of full-thickness epidermis with intact intercellular junctions, a key distinction from the blisters seen in pemphigus.