What is bullous pemphigoid?

➢ distinctive acquired blistering disorder with an autoimmune basis ➢ Blistering in BP is triggered by the linear deposition of autoreactive IgG antibodies and complement in the epidermal basement membrane ➢ The proteins that are recognized by the autoantibodies have structural roles in dermoepidermal adhesion. ➢ Bullous pemphigoid and ➢ pemphigus vulgaris are thus caused by similar pathogenic mechanisms, but differ in their clinical presentation and course due to variation in the location of the target antigen