What are breast-implant associated anaplastic large cell lymphoma?

➢ Morphology and immunophenotype similar to those of ALK-negative ALCL ➢ Arises around a breast implant ➢ Usually confined by a fibrous capsule. ➢ The average patient age at diagnosis is 52 years ➢ The median time from implant placement to clinical presentation is 8–9 years ➢ Most patients present with unilateral effusion around the implant ➢ One third of patients present with a mass, and about 20% develop regional lymphadenopathy, ➢ Approximately 5% of cases are bilateral. ➢ Surgery is the cornerstone of therapy, with complete excision of capsule and implant leading to a 5-year overall survival rate of 100% in patients with effusion only