What is myeloid sarcoma?

• Extramedullary tumor mass of neoplastic immature myeloid (granulocytic or monocytic) cells • Also called extramedullary myeloid tumor, granulocytic sarcoma, chloroma • Lymph nodes, subperiosteal bone, skin, orbit, spinal canal and mediastinum • May or may not be associated with a myeloid neoplasm in the BM. It is considereddiagnostic of (AML) and should be classified and treated accordingly, regardless of the BM or PB status. • May be the 1st manifestation of AML or may signal relapse in a previously treated patient. It may also signal transformation to acute leukemia in patients with MPN or MDS