What are SNRIs?

Block serotonin and NE reuptake like TCA, effective in pain relief (diabetic neuropathy, fibromyalgia and low back pain) Discontinuation syndrome Include (Venlafaxine (long acting, potent blocker, high dose blocks NE reuptake, increase BP and HR) Duloxetine (block both NE and SA at all doses, for Depression, GAD, SAD, diabetic neuropathy) Side effects (sexual dysfct)