How is aGVHD prophylaxis?

Most use calcineurin inhibitors (tacro/CSP) + MTX given days 1,3, 6 +/- 11 for sib/URD BM/PBSC Some programs use Mycophenylate mofetil (MMF) instead of MTX Mycophenylate mofetil (MMF) used for cords by most Other agents that can be used: sirolimus, ATG, prednisone, post-transplant cyclophosphamide, T-cell depletion Complete removal of T-cells Excess infections, rejection, relapse can occur Different types of depletion have different risks