What is pathophysiology of myocardial reperfusion?

• Prevention of cell death by restoration of blood flow depends on the severity and duration of the preexisting ischemia • Earlier blood flow is restored, the more favorable the recovery of LV systolic function, improvement in diastolic function, and reduction in overall mortality. • Even after successful reperfusion and despite the absence of irreversible myocardial damage, a period of postischemic contractile dysfunction can occur—a phenomenon called myocardial stunning.