How is pathophysiology of Sjogren?

Glandular dysfunction in Sjögren's syndrome (SS) is generally presumed to result from autoimmune-induced inflammation and resultant damage and destruction of the tissue responsible for tear and saliva production Glandular inflammation by overexpression of IFN apoptosis by SSA Ag to salivary and epithelial cells, lymphocytic infiltrates in salivary and lacrimal glands, focal aggregates of lymphocytes involve the lobule, migration of lymphocytes in response to chemokines, and adhesion molecules