How is pathogenesis of SLE?

Apoptosis (abnormal, source of autoantigen, UV induced in skin and impaired clearance) Nucleic acids (target in SLE linked to apoptosis, loss of T cell tolerance and self-recognition) Innate immunity (TLRs and inflammasomes on cell membranes activate Dc, Dc autophagy occurs and regulates IFNa prodcution and makes APCs to CD4+ T cells, IFNa activates autoantibodies specific, complement clearance of apoptotic material, Neutrophils promote inflammation, and endothelia impaired repair due to DNA degradation) Adaptive immunity (T and B cells activated polyclonal B cells form autoantibodies, B lymphocyte stimulator soluble TNF for B cell survival and differentiation, Immune complexes impaired clearance cause tissue injury at sites like skin and kidney)