How is epidemiology of SLE?

WW, radial variation (black, chinese and asian more common), prevalence 12-50/10000, female predominance 9 to 1 (increases during child bearing age 30 to 1. Genetics (familial aggregation [5-12%, concordance increase risk in monozygotic twins to 24-70% and dizygotic to 2-5%] HLA II DR2 and DR3 involved, inheritied complement deficiencies involved (C1q, C2, C4), some may influence clinical manifestations) Environmental (Physical [UV, thermal burns], chemical [drug], infectious [EBV], hormonal [estrogens], and autoantiboides)