Toxic Epidermal Necrolysis 1 Manifestations: 2 Characteristic Features: 3 Drugs that contribute: 4 Mediators (they induce TEN)

1 - Burning skin - Big blisters - Death from infections (sepsis) 2 - Apoptosis (cell death) of epidermal keratinocytes 3 - Anticonvulsants - Nonsteroidal anti-inflammatories (NSAID) - Antibacterial - Sulfonamides- Allopurinol - Nevirapine 4 - Tumor necrosis factor (TNF) - FAS ligands