How is cholinergic neurotransmission?

Ach neurotransmitter is seen in preganglionic fibers of ANS, postganglionic of parasympathetic, preganglionic fibers terminating in adrenal medulla. Cholinergic neurons innrevate muscles of somatic system, play important role in CNS (Patients with Alzheimers have loss of cholinergic neurons in temporal lobe and entorhinal cortex, most drugs that treat diseases are Achesterase inhibitors) It is in postganglionic for sympathetic varicosities innervating sweat glands in skin.