What is the hemodynamic factor in thrombosis?

In normal laminar blood flow, platelets (and other blood cells) are mostly found in the center of the vessel's lumen, separated from the endothelium by a slower-moving layer of plasma. main causes (veins [varicose/prolonged immobilization], arteries [aneurysm/hypotension]) Deleterious effects (endothelial cell activation stimulate procoagulant activity, stasis gets platelets and leukocytes to come into contact w/endothelia, slows clearance of clotting factors and hinders influx of clotting factor inhibitors, endothelial hypoxia)