TOXICOLOGY: C. TISSUE REPAIR
(Side Reactions to Tissue Injury)
b) Altered Protein Synthesis: Acute- Phase Proteins

1 Cytokines released from activated macrophages and endothelial cells at the site of injury also may evoke __. Thus, IL1, IL6 & TNF alter the temperature set point of the hypothalamus, triggering fever.

2 act on the pituitary to induce the RELEASE OF
(Adrenocorticotropic hormone) ACTH, which in turn stimulates the SECRETION OF CORTISOL from the adrenals

Question

C. TISSUE REPAIR
(Side Reactions to Tissue Injury)
b) Altered Protein Synthesis: Acute- Phase Proteins

1 Cytokines released from activated macrophages and endothelial cells at the site of injury also may evoke __.  Thus, IL1, IL6 & TNF alter the temperature set point of the hypothalamus, triggering fever.

2 act on the pituitary to induce the RELEASE OF
(Adrenocorticotropic hormone) ACTH, which in turn stimulates the SECRETION OF CORTISOL from the adrenals

LEIGHTON DWIGHT OBILLOS · Accepted Answer

1 neurohormonal responses

2) IL1 and IL6
- This represents a NEGATIVE
FEEDBACK LOOP because
corticosteroids inhibit
cytokine gene expression

TOXICOLOGY

1 neurohormonal responses 2) IL1 and IL6 - This represents a NEGATIVE FEEDBACK LOOP because corticosteroids inhibit cytokine gene expression

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