D. 1 (mitochondrial permeability transition) MPT is caused by (the process)

1 opening of a proteinaceous pore (permeable to solutes of 1500 Da.) 2 opening permits free influx into the matrix space of protons (rapid and complete dissipation of the membrane potential, cessation of ATP synthesis, osmotic influx of water causing mitochondrial swelling) 3) Ca2+ accumulated in the matrix space effluxes through the pore, flooding the cytoplasm. 4 glycolysis may become compromised by the insufficient ATP supply to the glycolytic enzymes that require ATP