D. 1 are all considered as CAUSATIVE FACTORS of an abrupt increase in the Mitochondrial Inner membrane Permeability (or mitochondrial permeability transition), termed MPT.

. 1 Mitochrondrial Ca2+ uptake, 2 Decreased mitochondrial membrane potential, 3 Generation of ROS and RNS, 4 Depletion of ATP 5 consequences of the Primary metabolic disorders