What are the classes of mutations in cancers?

Driver (pathogenic, alter function of cancer gene giving cancer, acquired by gene rearrangments [overexpression, especially hematopoeitic like Burkitt lymphoma t(8:14) in more than 90%, overexpression of MYC], deletions [tumor suppressor, RB 13q14 retinoblastoma, 17P TP53], amplification [increases oncogenes, NMYC neuroblastoma, HER2 breast cancer]) Passenger (acquired mutations don't affect cell behavior, may become driver if pressure on tumor changes like medication) Point mutations (can convert proto-oncogenes to oncogenes gain-of-function, like RAS gene, or loss-of-function like TP53 tumor suppressor gene) Aneuploidy (seen in carcinoma, increase oncogenes (MYC) and decrease tumor suppressors (TP53) miRNA (negative regulator of genes, leads to over and underproduction of oncogenes)