How is the prognosis of AIH?

Spontaneous remission: 13-20% of patients -> an unpredictable event Role of liver inflammation: severe initial presentation =worse long-term outlook than mild initial disease Development of multiple relapses-> worse long-term prognosis The role of HLA type: HLA DR3-positive patients are more likely to have active disease and are less responsive to therapy Hepatocellular carcinoma (HCC)-> Surveillance abdominal imaging studies (eg, ultrasound, CT, MRI) +alpha-fetoprotein testing every 6 month