What is aspirin induced asthma?

Acute idiosyncratic rxn leading to acute bronchospasm or angioedema (and rarely both) Evolves over decades, begins as chronic rhinitis (recurrent sinusitis and polyposis) Then asthma appears severe and requiring steroids We note brochospasm after 30 min to hour of admin of aspirin, maybe cross sensitivity with NSAIDs (PG synthesis inhibitors), blocking cyclooxygenase pathway thus producing more LTs which are potent inflammatory mediators inducing asthma pathophysio 3-5% of asthmatics hospitalized as aspirin reaction. Treatment avoidance/ desensitization by increasing dose of aspirin/ LT inhibitors and receptor antagonists