PHARMACOLOGY 2: It directly inhibits renin and, thus, acts earlier in the renin–angiotensin–aldosterone system than ACE inhibitors or ARBs.

It lowers bp about as effectively as ARBs, ACE inhibitors, and thiazides.

It should not be routinely combined with an ACE inhibitor or ARB.

Question

It directly inhibits renin and, thus, acts earlier in the renin–angiotensin–aldosterone system than ACE inhibitors or ARBs.

It lowers bp about as effectively as ARBs, ACE inhibitors, and thiazides.

It should not be routinely combined with an ACE inhibitor or ARB.

LEIGHTON DWIGHT OBILLOS · Accepted Answer

RENIN INHIBITOR

It directly inhibits renin and, thus, acts earlier in the renin–angiotensin–aldosterone system than ACE inhibitors or ARBs. It lowers bp about as effectively as ARBs, ACE inhibitors, and thiazides. It should not be routinely combined with an ACE inhibitor or ARB.