PHARMACOLOGY 1: CATHECHOL-O-METHYLTRANSFERASE (COMT)
INHIBITORS (Selectively and Irreversibly)

DECREASES plasma concentrations of 3-O-METHYLDOPA
INCREASES uptake of LEVODOPA

REDUCES the symptoms of "WEARING OFF" phenomena in Levodopa-Carbidopa

Adverse Effects: Same with Levodopa

Question

CATHECHOL-O-METHYLTRANSFERASE (COMT)
INHIBITORS (Selectively and Irreversibly)

DECREASES plasma concentrations of 3-O-METHYLDOPA 
INCREASES uptake of LEVODOPA

REDUCES the symptoms of "WEARING OFF" phenomena in Levodopa-Carbidopa

Adverse Effects: Same with Levodopa

LEIGHTON DWIGHT OBILLOS · Accepted Answer

1 Entacapone 
- (Safer)

2 Tolcapone 
- (Longer duration of action)
- (but causes HEPATIC NECROSIS)

CATHECHOL-O-METHYLTRANSFERASE (COMT) INHIBITORS (Selectively and Irreversibly) DECREASES plasma concentrations of 3-O-METHYLDOPA INCREASES uptake of LEVODOPA REDUCES the symptoms of "WEARING OFF" phenomena in Levodopa-Carbidopa Adverse Effects: Same with Levodopa