1 In Osmotic Pump, the drug release rate may be altered by: 2 In Osmotic Pump, drug release is not affected by: 3 Osmotic Pump Example:

1 -Changing Surface area -Thickness or composition of the membrane -Changing the diameter of the drug release 2 GI Acidity, Alkalinity, Fed conditions, or GI motility 3 Gastrointestinal Therapeutic system (GITS), Adalat GITS