• Function: It is involved as a coenzyme for many enzymes, especially those involved in energy metabolism. • as a treatment for High Cholesterol. • High-dose niacin supplements can improve blood lipid profiles • At doses of 1500 mg per day, it decreases low-density lipoprotein cholesterol and triglyceride levels • However, patient with CV diseases who tale a statin medication do not benefit further from supplemental niacin; thus it is not recommended to take both