What does Defects in leukocyte adhesion cause?

Leukocyte ahesion deficiencies (LADs) 1, 2 and 3. fail to migrate to the infection sites due to defects in adhesion LDA-1. It is caused by mutations in CD18 gene of β-2 integrins LDA-2. A mutation in the fucose transporter to the Golgi apparatus. LDA-3. A defect that inhibits signal transduction in integrins. Lack of integrin activation results in reduced ability of leukocytes to bind endothelial cells to extravasate