Pregunta:
What is Allelic exclusion relation the b-cell selection?
Autor: Shay 1vccRespuesta:
Pre-BCR complex also send signal to inhibit recombination on the homologous chromosome, so only one allele will express BCR of single specificity. -If k light chain fail to produce functional receptor or k light chain encodes a self-reacting BCR, then BCR will trigger recombination of k with ⋋ light chain. If functional IgM receptor is produced it will send survival signal, otherwise – apoptosis. Signals from IgM will also shut off light chain recombination, so either k or ⋋ light chains are made by given B cells.
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