Pregunta:
What are the mechanisms that drive selection of B cell?
Autor: Shay 1vccRespuesta:
Only cells that express Igm heavy chain are selected to survive to become pre-B cells. Igm heavy chain and surrogate light chains are expressed on cell surface and associate with Iga and Igb to form pre-BCR complex. Pre-BCR complex is a first checkpoint for cells that express functional Igm heavy chain. It sends survival signals. If Igm heavy chain is failed to be made – pre-B cells will die by apoptosis= first checkpoint.
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