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level: Level 4 - TABLETS

Questions and Answers List

level questions: Level 4 - TABLETS

Question	Answer
 Are medicinal agents or inert substances that are ENCLOSED IN A SMALL SHELL OF GELATIN. (STATE THE ADV & DISADV)	CAPSULES ADV: (1) It is tasteless and easily administered (2) easily filled extemporaneously or in large quantities commercially available (3) Flexibility in exact dosage level. disadv: 1 NOT FOR administration of extremely soluble materials like POTASSIUM CHLORIDE, POTASSIUM BROMIDE, OR AMMONIUM CHLORIDE. 2 NOT used for HIGHLY EFFLORESCENT & DELIQUESCENT MATERIALS.
prepared by the ENZYMATIC HYDROLYSIS OF COLLAGEN. The main protein constituent is the main constituent of the connective tissues in animal bones and skin. Made up either of cow or pig	Gelatin
1 ACID HYDROLYSIS of PORCINE SKIN. 2 BASE HYDROLYSIS from BOVIN BONES	1 Gelatin A 2 Gelatin B
 Also known as DRIED FILLED CAPSULE.  Main component: They are shell made form GELATIN + SUGAR + WATER. FD&C colorant is added and OPACIFYING AGENT. Added with 0.15% SULFUR DIOXIDE (prevent the decomposition of hard gelatin during the manufacturing) Contains 12-16% MOISTURE	Hard Gelatin Capsules
Hard Gelatin Capsules 1 Main component 2 (prevent the decomposition of hard gelatin during the manufacturing) 3 Techniques on how to fill hard gelatin capsule	. 1GELATIN + SUGAR + WATER. FD&C colorant is added and OPACIFYING AGENT. 2) add 0.15% SULFUR DIOXIDE 3) 1 Punch method 2 Hand Operated Filling Machine
 Soft, globular gelatin shell that is somewhat thicker than that hard gelatin capsules.  Made up of GELATIN + GLYCERINE OR POLYHYDRIC ALCOHOL such as SORBITOL. May also contains preservatives to prevent growth of fungi  Contains at least 6-10% MOISTURE. Used for: Water-immiscible volatile and nonvolatile liquids, Water-miscible non-volatile liquids, and Water-miscible and relatively nonvolatile compound	Soft Gelatin Capsules
Soft Gelatin Capsules 1 Used for the elasticity and plasticity of soft gelatin capsules	. 1 Glycerine & Sorbitol
Soft Gelatin Capsules PROCEDURES	1 Milling 2 Sieving to achieve the desired size for product After that, 1 blending, 2 capsule filling, 3 capsule sealing through KAPSEAL SEALING or HEAT WELDING, 4 capsule cleaning, 5 polishing, and 6 inspection and weighing.
Soft Gelatin Capsules Capsule Sealing through __	KAPSEAL SEALING or HEAT WELDING,
 May be PREPARED BY WET GRANULATION, DRY GRANULATION OR THROUGH DIRECT COMPRESSION.  They are MADE FROM POWDER CRYSTALLINE or granular materials (alone or in combination with binders, disintegrants, controlled release polymers, lubricants, diluents, and in many cases colorant.  The vast majority of tablets that is available commercially are __. Either in uncoated or coated state.	COMPRESSED TABLETS
- Compressed tablets that are COATED WITH THE USE OF SUGAR. - Sugar is used to mask the bitter taste of compressed tablets. - It ensures palatability of tablets. However, it can also ADD 50% TO THE TABLET SIZE OR BULK.	Sugar Coated
Sugar Coated 1 - __ is used to mask the bitter taste of compressed tablets. - It ensures palatability of tablets. However, it can also ADD 50% TO THE TABLET SIZE OR BULK.	Sugar
- They are broken and intended to be CHEWED BEFORE INGESTION. - Usually ADD MANNITOL & XYLITOL (sugar free). - With the addition of mannitol, you can add 50% of the total weight of the tablet	Chewable Tablets
Chewable Tablets 1 - Usually ADD __ (sugar free). 2 With the addition of __, you can add 50% of the total weight of the tablet	. 1 MANNITOL & XYLITOL 2 mannitol
- The tablet is coated with a THIN LAYER OF POLYMER that is capable in FORMING A SKIN-LIKE FILM. - It is advantageous with sugar coated tablet since the END PRODUCT IS LESS BULKY	Film coated
- These are coated so that, it can only release or DISINTEGRATE IN THE INTESTINAL FLUID. - Therefore, they have DELAYED RELEASE FEATURES.	Enteric Coated Tablet
- This is COMPRESSING the FILM MATERIAL MORE THAN ONCE.	Multiple Compressed Tablet
Multiple Compressed Tablet TYPES	1 Layered 2 Pressed coated or Dry coated
- Prepared by COMPRESSING ADDITIONAL TABLET GRANULATION on previously COMPRESSED GRANULATION. - This operation is repeated to give a multiple layered tablets with 2 OR 3 LAYERS	Layered
- Tablet within a tablet. You LAYER A TABLET WITH A TABLET. Prepared by FEEDING previously COMPRESSED TABLET into a SPECIAL TABLETING MACHINE and then COMPRESSING ANOTHER GRANULATION LAYER around the pre-formed tablets. (STATE THE ADVANTAGE OF THIS) (GIVE EXAMPLE OF THIS)	Pressed coated or Dry coated ex. NEOZEP (Noon) ADVANTAGE: - It can be USED IN SEPARATING INCOMPATIBLE DRUG SUBSTANCES within the formula. Especially if they are composed of multiple active ingredients. - provide enteric coating in cord tablet
- Also known as PROLONGED-RELEASE or SUSTAINEDRELEASE. - These tablets are intended to be RELEASED OVER A PERIOD OF TIME. - The active ingredients or therapeutic ingredients are released over a period of time. - The RELEASE of active ingredient is STAGGERED	Controlled-release Tablet
- USED FOR PREPARING SOLUTIONS or imparting given characteristics to a solutions. - Usually labelled to be INDICATED THAT THEY ARE NOT TO BE SWALLOWED. (GIVE EXAMPLE OF THIS)	Tablets For Solution - Ex: 1 Halazone (gives antiseptic characteristics to the solutions) and 2 potassium permanganate tablets for solution.
1 Tablets For Solution EXAMPLES 2 (gives antiseptic characteristics to the solutions)	1 Halazone, Potassium Permanganate tablets for solution. 2 Halazone