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level: level 6

Questions and Answers List

level questions: level 6

Question	Answer
tx for infections caused by multiply resistant bacteria and for empirical therapy for serious infections such as bacterial meningitis, septicaemia, pneumonia and peritonitis 2nd generation carbapenem greater potency against gram - and anaerobic bacteria not active orally not degraded by renal peptidases no S/E with that of Imipenem Ertapenem and Biapenem	Meropenem
Isolated from Cephalosporium spp. or prepared semi synthetically	CEPHALOSPORINS
inhibited growth of wide variety of gram + and gram - bacteria	C. acremonium - by 1945: Giuseppe Brotzu
1 isolated three principal antibacterial activity: 2 three principal antibacterial activity:	1 1948: Abraham and Newton 2 Cephalosporin P1, Cephalosporin N, Cephalosporin C
1 steroid with minimal antibacterial act. 2 identical to synnematin N (penicillin N), C. salmosynnematum	1 Cephalosporin P1 2 Cephalosporin N
1 Drug of choice for surgical prophylaxis 2 Active against H influenza but not Serratia or B fragilis	1 Cefazolin 2 Cefaclor, cefamandole, cefonicid, cefuroxime, ceforanide
1 Used to treat mixed anaerobic infections such as peritonitis or diverticulitis 2 For community acquired pneumonia 3 Active against P aureginosa	1 Cefoxitin, cefotetan or cefmetazole 2 Cefuroxime 3 Ceftazidime & Cefoperazone
weakly active but highly resistant to B-lactamases isolations of Sulfacezin (SQ 26,445) from saprophytic soil bacteria in Japan and US	MONOBACTAMS
can be use with Pen allergy active against aerobic bacteria, gram -ve bacilli> E.coli, K. pneumoniae, P. mirabilis, S. marcescens, Citrobacter spp binds with high affinity to PBP 3 in gram -ve only inactive against gram + and anaerobes Urinary and Respiratory infections, intra-abdominal infections, gynecological infections Given IV. Excreted through Renal	Aztreonam
newer monobactam, orally active very active against Enterobacteraceae, Klebsiella, E.coli, Citrobacter, Proteus good potency against H. influenzae, N. gonorrhoeae Good oral bioavailability	Tigemonam