What is rolling ?

TNF-a and IL-1 induce E-selectin expression on endothelial cells. Thrombin induces translocation of P-selectin to endothelial cell surface.Stable adhesion- chemokines secreted by macrophages and endothelial cells attach to endothelial cells and when bind to neutrophils increase affinity of integrins to integrin ligands on endothelial cells. Endothelial cells are stimulated by TNF-a and IL-1 to express ligands for integrins.