IV. NEUROMUSCULAR-BLOCKING DRUGS

These drugs block cholinergic transmission between motor nerve endings and the nicotinic receptors on the neuromuscular endplate of skeletal muscle. These neuromuscular blockers are structural analogs of ACh, and they act either as antagonists (nondepolarizing type) or agonists (depolarizing type) at the receptors on the endplate of the NMJ.