Nicotine

Increased blood pressure and cardiac rate (due to release of transmitter from adrenergic terminals and from the adrenal medulla) and increased peristalsis and secretions. At higher doses, the blood pressure falls because of ganglionic blockade, and activity in both the GI tract and bladder musculature ceases.Generalized ganglionic stimulation: hypertension, tachycardia, nausea, vomiting, diarrhea • For smoking cessation, usually used as gum or transdermal patch Duration: 4–6 h Major overdose: convulsions, paralysis, coma