Neostigmine 3. Adverse effects:

Adverse effects of neostigmine include those of generalized cholinergic stimulation, such as salivation, flushing, decreased blood pressure, nausea, abdominal pain, diarrhea, and bronchospasm Increased parasympathetic effects, especially nausea, vomiting, urinary urgency. Neostigmine does not cause CNS side effects and is not used to overcome toxicity of central-acting antimuscarinic agents such as atropine. Neostigmine is contraindicated when intestinal or urinary bladder obstruction is present. It should not be used for patients who have peritonitis or inflammatory bowel disease