Pregunta:
Drugs that stimulate one receptor but block another are termed mixed agonist-antagonists. The effects of these drugs depend on previous exposure to opioids. In individuals who have not recently received opioids (naïve patients), mixed agonist-antagonists show agonist activity and are used to relieve pain. In the patient with opioid dependence, the agonist-antagonist drugs may show primarily blocking effects (that is, produce withdrawal symptoms).
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V. MIXED AGONIST-ANTAGONISTS AND PARTIAL AGONISTS
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