It can produce physical dependence like that of morphine but has less neurotoxicity than what is seen with morphine due to the lack of active metabolites. Methadone can cause torsades de pointes in certain situations. Overdosing is possible when prescribers are not aware of the incomplete cross-tolerance between methadone and other opioids, the long half-life associated with methadone and the proper titration guidelines to avoid its accumulation, and the multiple drug-drug interactions that can occur with this agent.